Welcome to Yoon Research Group~!!
If you have any questions, feel free to contact me at hyoon(a)chonnam.ac.kr

Research in our group focuses on rational design, synthesis, and
applications of functional nanomaterials which mainly consist of
conducting polymers, carbon nanotubes, and graphene.

본 연구실은 기능성 나노재료의 디자인, 합성 및 응용에 관한 연구를
중점적으로 진행하고 있습니다.

1) 전도성 고분자, 탄소 나노튜브, 그래핀으로 구성된 나노재료의
구조 및 물성 제어
2) 열/전기 전도, 접착, 부식방지 특성의 기능성 고분자 나노복합재료
제조, 분석 및 응용
3) 전자 장치, 화학/바이오 센서 및 각종 에너지 분야에서 기존 장치의
성능 향상 또는 신개념의 장치 개발

(1) Global Ph.D. Fellowship
Chul Soon receives Global Ph.D. Fellowship from the National Research Foundation of Korea. The fellowship supports outstanding graduate students to nuture world-class academics and researchers in South Korea. This year, 200 students were selected from more than 1,000 applicants.

(2) Guest Editor, Applied Sciences
: Prof. Yoon now serves as a Guest Editor for a Special Issue "Recent Trends in Polymer Nanoscience and Nanotechnology" in Applied Sciences. Visit the website "http://www.mdpi.com/journal/applsci/special_issues/Polymer_Nano".

(3) Our heavy metal sensors article has been selected as a "Hot Article"
: Visit the Analyst Blog "http://blogs.rsc.org/an/category/hot-article/"


(1) Biosens. Bioelectron. 2018, 105, 151-158.
"Fast and sensitive near-infrared fluorescent probes for ALP detection and 3d printed calcium phosphate scaffold imaging in vivo"


Alkaline phosphatase (ALP) is a critical biological marker for osteoblast activity during early osteoblast differentiation, but few biologically compatible methods are available for its detection. Here, we describe the discovery of highly sensitive and rapidly responsive novel near-infrared (NIR) fluorescent probes (NIR-Phos-1, NIR-Phos-2) for the fluorescent detection of ALP. ALP cleaves the phosphate group from the NIR skeleton and substantially alters its photophysical properties, therefore generating a large “turn-on” fluorescent signal resulted from the catalytic hydrolysis on fluorogenic moiety. Our assay quantified ALP activity from 0 to 1.0 U/mL, showing a response rate completed within 1.5 min. A potentially powerful approach to probe ALP activity in biological systems demonstrated real-time monitoring using both concentration- and time-dependent variations of endogenous ALP in live cells and animals. Based on high binding affinity to bone tissue of phosphate moiety, bone-like scaffold-based ALP detection in vivo was accessed using NIR probe-labeled three-dimensional (3D) calcium deficient hydroxyapatite (CDHA) scaffolds. They were subcutaneously implanted into mice and monitored ALP signal changes using a confocal imaging system. Our results suggest the possibility of early-stage ALP detection during neo-bone formation inside a bone defect, by in vivo fluorescent evaluation using 3D CDHA scaffolds.
(2) Biosens. Bioelectron. 2017, 89, 919.
"A Near-Infrared "Turn-On" Fluorescent Probe with a Self-Immolative Linker for the In Vivo Quantitative Detection and Imaging of Hydrogen Sulfide"


Hydrogen sulfide is a critical biological messenger, but few biologically compatible methods are available for its detection in vivo. Here, we describe the design and synthesis of a novel azide-functionalized near-infrared probe, NIR-Az, for a hydrogen sulfide assay in which a self-immolative linker is incorporated between the azide moiety and phenolic dihydroxanthene fluorophore from a cyanine dye. A large “turn-on” near-infrared fluorescence signal results from the reduction of the azide group of the fluorogenic moiety to an amine, in which the self-immolative linker also enhances the accessibility of NIR-Az to hydrogen sulfide. NIR-Az can select hydrogen sulfide from among 16 analytes, including cysteine, glutathione, and homocysteine. By exploiting the superior properties of NIR-Az, such as its good biocompatibility and rapid cell internalization, we successfully demonstrated its usefulness in monitoring both the concentration- and time-dependent variations of hydrogen sulfide in living cells and animals (detection limit less than 0.26 μM), thereby providing a powerful approach for probing hydrogen sulfide chemistry in biological systems.

School of Polymer Science & Engineering, 77 Yongbong-ro, Buk-gu, Gwangju 61186, South Korea

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